Intralesional and sublesional injections of relatively insoluble corticosteroids are still necessary for localized chronic dermatologic lesions where prolonged oral corticosteroid therapy is not desirable and where topical corticosteroid therapy, even the occlusive dressings or so-called surface depot therapy, is not effective. Reactions following intralesional and sublesional injections of corticosteroids are uncommon in relation to the large number of injections which are given. These uncommon reactions may be either local or even rarer, systemic types. Local reactions may include among others, transient atrophy, secondary infections and hypersensitivity reactions. Suggestions are offered to reduce the frequency of these reactions although it is recognized that they may occur in spite of all precautions and care.