After accurate isolation, 126 peripheral nerves were blocked with 2% or 3% phenol solutions in distilled water in 68 patients with severe spasticity of various causes. Seven nerve blocks were repeated. The period of effectiveness ranged from 2 to 743 days, with an average of 308 days. Paresthesia occurred following ten nerve blocks. Gain and loss of voluntary movement following the blocks were observed. Ease, simplicity, safety, therapeutic benefits, and economic advantages of peripheral nerve block with phenol warrant its more widespread use.