We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

LE Cell Test and Antinuclear Antibodies

Edmund L. Dubois, MD
JAMA. 1967;200(12):1053-1054. doi:10.1001/jama.1967.03120250087017.
Text Size: A A A
Published online


Since Hargraves' description of the LE cell in 1948, our understanding of systemic lupus erythematosus (SLE) has made rapid strides.1 Extensive investigations into the immunological and clinical implications of this finding have greatly changed our concept of the disease and have shown that it is a relatively common disorder.2

It is currently believed that LE cell formation is due to an antibody to nucleoprotein.3 Patients with SLE also have many other antibodies, most important and specific of which may be the one against deoxyribonucleic acid.4

Serologic Tests for Systemic Lupus Erythematosus  Antinuclear antibody tests have been extensively studied during the past 12 years. They are useful for the diagnosis of SLE and other autoimmune disorders but their sensitivity and specificity cannot be correlated between laboratories since there are no standard reagents or test sera. Consequently, each laboratory must have its own control studies of the incidence


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.