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ARTICLE |

Intravenous Administration of Furosemide in Heart Failure

Michael Davidov, MD; Nikos Kakaviatos, MD; Frank A. Finnerty Jr., MD
JAMA. 1967;200(10):824-829. doi:10.1001/jama.1967.03120230076009.
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Furosemide was administered intravenously to 41 patients with edema who had become refractory to both thiazides and organomercurials. Repeated doses of 80 to 160 mg completely cleared peripheral edema in all patients and pulmonary congestion (roentgenographically demonstrated) in nine of 12 patients by the fifth day. Fifteen minutes after the injection, there was a 13-fold increase in urinary output and more than a fourfold increase in urinary sodium excretion. The urinary sodiumpotassium excretion ratio during furosemide-induced diuresis was increased more than onefold. Potassium excretion was not increased unless excessive diuresis occurred.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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