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Thymic Tumor and Erythroblastic Aplasia

C. William H. Havard, D.M., M.R.C.P.; J. Anthony Parrish, M.B., M.R.C.P.
JAMA. 1962;179(3):228-230. doi:10.1001/jama.1962.03050030042012b.
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THE ASSOCIATION of a thymic tumor with selective aplasia of erythrocytes has aroused considerable interest over the last decade. Our knowledge of the syndrome has recently been reviewed. One of the curious features of this association is that erythroblastic aplasia may follow some years after the removal of a symptomless thymic tumor, although this has only been reported on 2 occasions. We feel that the following case is worthy of note, as it provides a further instance of this latent interval. Furthermore, remission of erythropoietic failure was achieved by splenectomy and steroid therapy, although neither treatment had been effective by itself.

Report of a Case

A 53-year-old woman with dyspepsia was examined in December, 1954. There were no physical signs of disease and no evidence of myasthenia, nor was there anemia (hemoglobin 14.5 gm/100 ml.). A radiograph of the chest showed a smooth, lobulated tumor in the anterior mediastinum. A


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