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Hepatitis Associated with a Coxsackie B5 Virus Infection During Late Pregnancy

William J. O'Shaughnessey, M.D.; Howard A. Buechner, M.D.
JAMA. 1962;179(1):71-72. doi:10.1001/jama.1962.03050010000017.
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THE FOLLOWING account concerns a female in her seventh month of pregnancy who suffered a severe infection with Coxsackie B5 virus involving multiple organ systems. The case was considered worthy of special comment because hepatic damage was present. In addition, the striking similarity of the clinical picture to that usually produced by Weil's disease was thought to be of unusual interest.

Report of a Case

A 21-year-old white female was admitted to Charity Hospital of Louisiana on Oct. 23, 1959, with a diagnosis of "meningitis." The patient was 7 months pregnant (gravida 6, para 5). She had been in good health until 7 days prior to admission, when she developed a generalized headache, malaise, and a low-grade fever. Her physician felt that she had "flu" and treated her with tetracycline, 250 mg. every 6 hours. Two days later she developed projectile vomiting without nausea. At this time she was admitted


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