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Experimental Production of Coronary Arteriosclerosis in Normotensive Animals

Sam E. Stephenson Jr., M.D.; Rachel Younger, B.A.; H. William Scott Jr., M.D.
JAMA. 1962;179(1):46-48. doi:10.1001/jama.1962.03050010000008c.
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IN RECENT YEARS, with increasing importance being placed on the cause and the prevention of arteriosclerosis, the experimental production of these lesions has become rather commonplace in the medical literature. Experimental atherosclerosis can be easily induced in the chicken and rabbit, and more recently a regimen has been utilized which has made reproducible lesions possible in the dog. Though large vessel lesions (aorta, carotid, femoral, and so forth) have not been difficult to obtain; there has been some difficult)- in producing coronary arteriosclerosis in the otherwise intact animal, and a method of producing this lesion is the basis of this report.

The recent developments of techniques and procedures satisfactory for the treatment of coronary arteriosclerosis or for myocardia] revascularization have added further impetus to the problem of creating the lesion experimentally so that an adequate test of the postulated surgical procedures may be carried out. It is well known that


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