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Quick's One-Stage Prothrombin Time

I. Myron Vigran, M.D.
JAMA. 1961;178(11):1118-1119. doi:10.1001/jama.1961.03040500060017.
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To the Editor:—  It is with some difficulty that I have interpreted Dr. Quick's comments (JAMA176:1127 [July 1] 1961) on my article concerning the Thrombotest (JAMA176:188 [April 22] 1961). Apparently he was referring to procedures used in my study which were termed the Quick one-stage prothrombin time. Dr. Quick is correct in pointing out this error, since the determinations used were a modification of his procedure.Dr. Quick neglected to state that his method does not detect Factor IX (Christmas), which is one of the factors reduced by the administration of oral anticoagulants; nor is he correct in stating that his one-stage test is the only reliable method for determining active prothrombin in human blood. Various modifications of his procedure have been used with success for years, and indeed, the unmodified Quick one-stage prothrombin time is not in general use. The majority of patients receiving anticoagulant


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