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Immunization of Preschool Children with Oral Poliovirus Vaccine (Sabin)

D. M. Horstmann, M.D.; J. R. Paul, M.D.; M. Godenne-McCrea, M.D.; R. H. Green, M.D.; E. M. Opton, Ph.D.; A. I. Holtz, M.D.; J. C. Niederman, M.D.
JAMA. 1961;178(7):693-701. doi:10.1001/jama.1961.03040460001001.
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The effectiveness of an oral polivirus vaccine using Sabin strains was studied among some 350 preschool children beginning in January, 1960. Although 79% of the children had previously received 3 or more doses of killed virus vaccine, a relatively high per cent lacked antibody to one or more types, and 22% of 348 children were triple negatives. The oral vaccine was given according to 3 different dosage schedules: each type singly; Type 1 followed by Types 2 and 3 together; and trivalent vaccine twice, 6 weeks apart. The infection and antibody conversion rates were similarly high for all 3 schedules, the overall conversion rates being 95% for Type 1, 98% for Type 2, and 86% for Type 3. The results emphasize the desirability of oral vaccine for young preschool children regardless of previous administration of multiple doses of killed Salk-type vaccine.


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