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Multiple Concordant Abnormalities in 79-Year-Old Identical Twins

Lewis M. Schiffer, M.D.; Matthew Zucker, M.D.; Eugene L. Lozner, M.D.
JAMA. 1961;178(5):507-509. doi:10.1001/jama.1961.73040440021014b.
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THE CONCORDANT occurrence of disease and physical abnormalities in identical twins has been the subject of numerous reports. As far as we can determine, however, the 79-year-old identical twin sisters which we now present have a unique combination of illnesses. They both have pernicious anemia, peripheral facial nerve palsy, small bowel diverticula, and an asymptomatic sliding hiatus hernia. In addition, they both have had a benign intraductal papilloma of the breast and probably have had toxemia of pregnancy. Proof of their monozygosity is offered by means of skin cross-transplantation and identity of blood group factors.

Report of Cases 

Case 1.—  A 79-year-old woman states that in 1907 at the age of 25 she had convulsions before and during labor. In 1948 she suddenly developed a left peripheral facial nerve paralysis (Fig. 1). An upper gastrointestinal x-ray study in 1954 revealed the presence of several duodenal diverticula, and a sliding hiatus


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