0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

Amelioration of Sickle Cell Disease by Persistent Fetal Hemoglobin

John F. Jackson, M.D.; Janie L. Odom; Warren N. Bell, M.D.
JAMA. 1961;177(12):867-869. doi:10.1001/jama.1961.73040380028011b.
Text Size: A A A
Published online

THE CLINICAL manifestations of sickle cell anemia are thought to be due to the abnormal hemoglobin in the erythrocytes. In addition to Hemoglobin S, however, the erythrocytes of patients with sickle cell anemia may also contain fetal hemoglobin.1 Since sickling of erythrocytes is decreased by fetal hemoglobin,2 this study was undertaken to evaluate the effect of persistence of significant amounts of fetal hemoglobin on the clinical severity of the manifestations of sickle cell anemia.

Materials and Methods  Hemoglobin electrophoresis was performed on the red cell hemolysates of all University of Mississippi Medical Center patients suspected of having sickle cell anemia or trait. The filter paper electrophoresis technique of Motulsky et al.3 was used. This method was modified by decreasing the voltage from 260 to 120 and increasing the duration of electrophoresis run from 5 to 23 hours, thereby achieving a greater spread of resulting components. Fetal

Topics

Sign in to download this free article PDF

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in to download this free article PDF

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();