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The Human Blood Proteins: Methods of Examination and Their Clinical and Practical Significance

Martin E. Hanke, M.D.
JAMA. 1961;177(10):732. doi:10.1001/jama.1961.03040360068033.
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This is an extensive treatise covering both chemical and clinical aspects of the plasma proteins. In the title, "blood proteins" is misleading since hemoglobin and blood clotting are omitted entirely. The preparation, properties, and analytical procedures of each of the plasma proteins are discussed in detail. Theory and practice of salting in and salting out, electrophoresis, and of the ultracentrifuge are well covered. In the chapter "Clinical-Chemical Methods" the erythrocyte sedimentation rate, the Weltmann Coagulation band, and various turbidity and flocculation reactions are described.

More than two-thirds of the book is devoted to the clinical significance of the plasma proteins. This is treated separately (and somewhat repetitively) from 4 points of view: (1) reaction constellation, which is composite graphic representation of sedimentation, flocculation, and electrophoretic data in various classes of diseased states: inflammatory, proliferative, hepatitis, cirrhosis, obstructive jaundice, nephrotic, malignant tumor, and plasmocytoma; (2) individual analytical procedures; (3) individual diseases;


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