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Parkinsonism; Its Medical and Surgical Therapy

Leo Alexander, M.D.
JAMA. 1961;177(10):732. doi:10.1001/jama.1961.03040360068032.
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This book is an important landmark in our knowledge of the treatment of parkinsonism. After a brief review of the medical treatment and adjunctive treatments with their well-known limitations, the author presents the surgical treatment, its technique and its results, in gratifyingly full and meticulous detail.

The author himself originated and developed the most effective and practicable form of surgical treatment of parkinsonism available today, beginning with ligation of the anterior choroidal ( pallidohippocampal ) artery, which furnishes the sole blood supply of the medial and intermediate segments of the globus pallidus and participates in the blood supply of the lateroventral region of the thalamus. The author developed his techniques of chemopallidectomy and chemothalamectomy on the basis of his studies of 50 patients so operated upon. At the time of writing, the author had examined and studied 5,000 cases of parkinsonism and operated on 1,500 of them. Chemothalamectomy is at present his


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