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JAMA. 1961;177(10):702. doi:10.1001/jama.1961.03040360038007.
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The June meeting of the Association heard Boggs describe experiments in which a virus long cultivated in vitro apparently induced infectious hepatitis in human volunteers. In this issue of The Journal (p. 671) these trials are reported in greater detail with an account of the stubborn and patient laboratory experiments that preceded them.

Five years ago Rightsel and associates1 announced the cultivation of a virus found repeatedly in the serum of persons afflicted with hepatitis. Their method was unsatisfactory in 2 respects. The cultured cells required human serum for growth, which frequently introduced complicating factors. Moreover the signs of infection in the cultivated cells were often difficult for others to recognize. While the observations received the close attention of other virologists, few were convinced that the hepatitis virus had been cultivated. It is, therefore, greatly to the credit of the investigators that the studies were continued and carried to


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