We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |


JAMA. 1961;177(5):325-326. doi:10.1001/jama.1961.03040310043009.
Text Size: A A A
Published online


To the practitioner, histoplasmosis has been a late-comer to the diagnostic dilemma, and to many it still remains a puzzling one. Although fungi were the first etiologic agents of disease to be recognized (in favus in 1839), they had played almost no part in differential diagnosis, except for rare and always fatal exceptions, until 1937. Then the pioneer work of Gifford, Dixon, and Smith revealed that coccidioidomycosis was a common disease of the desert areas of California. It is now estimated that there are at least 10 million persons infected with this disease.

Histoplasmosis pursued a similar course, from 71 cases in 1945 to estimates of 30 million infected in 1950.1 The key to the detection of widespread infection was the skin test. Like tuberculin, it indicates infection past or present, rather than active disease. In each of these diseases, the skin test is an extremely specific and useful


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.