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Effect of an Autonomic Blocking Agent and a Vasopressor on Blood Flow

Enrique D. David, M.D.; Agostino Divella, M.D.; Harris B. Shumacker Jr., M.D.
JAMA. 1961;177(5):322-323. doi:10.1001/jama.1961.73040310019007.
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SINCE DeBakey and his colleagues clearly demonstrated the role of the "borrowing-lending" phenomenon in the distribution of blood flow,1 it should have been evident that vasodilators and autonomic blocking agents have no place in the treatment of localized circulatory impairment due to interruption of blood flow through the arterial stem supplying that segment. Nevertheless, some have continued to use these agents for acute and chronic arterial obstruction. It was the purpose of this study to evaluate the influence of tetraethylammonium (Etamon) chloride and of metaraminol (Aramine) bitartrate upon the arterial pressure distal to an acutely induced arterial block. The method of Longenecker, Reemtsma, and Creech2 was used.

Materials and Methods  Healthy mongrel dogs were anesthetized by the intravenous injection of thiopental sodium. Tracheal intubation was carried out, and the lungs were rhythmically insufflated with oxygen by means of a mechanical respirator. The dogs were heparinized, and the

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