Other Articles |

Methicillin Tolerance After Anaphylactoid Reactions to Penicillin G

Edgar F. Luton, M.D.
JAMA. 1961;177(2):152-153. doi:10.1001/jama.1961.73040280019016b.
Text Size: A A A
Published online

THE OCCURRENCE rate of anaphylactoid reactions to penicillin is in the thousands each year, and the mortality rate is estimated to be about 10 per cent.1 In the development of newer forms of penicillin, one of the primary interests has been the possibility of finding one that would not produce allergic reactions, especially in those already showing sensitivity to the older forms. Inasmuch as penicillin is not very antigenic in animals and information regarding antibodies from in vitro studies is scanty, knowledge of the characteristics of anaphylactoid penicillin allergy is secured only from clinical reports. The following cases are reported because of positive reactions to penicillin G (benzyl penicillin), with negative skin tests, and tolerance to full doses of sodium methicillin (Staphcillin), given intramuscularly.

Report of Cases 

Case 1.—  A 31-year-old male laborer was admitted to Kennedy VA Hospital on Nov. 13, 1960 because of an acute hallucinosis


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.