Other Articles |

Epidemic Bronchiolitis and Pneumonitis Related to Respiratory Syncytial Virus

John M. Adams, M.D.; David T. Imagawa, Ph.D.; Kenneth Zike, M.D.
JAMA. 1961;176(12):1037-1039. doi:10.1001/jama.1961.63040250020020b.
Text Size: A A A
Published online

THIS PRELIMINARY report describes an epidemic of acute respiratory disease in infants and children occurring during January, February, and March, 1961, and most probably due to respiratory syncytial (RS) virus. The epidemic is characterized by its predilection for young infants, by low-grade fever, cough, dyspnea, and cyanosis with signs of bronchiolar obstruction and pneumonitis. It is quite similar to an epidemic of primary virus pneumonitis with cytoplasmic inclusion bodies observed by Dr. Adams in January, February, and March, 1937, and first reported in 1941.1,2

In the present epidemic, a viral agent has been isolated in HeLa cells and primary monkey kidney cells directly from throat washings. Eight strains of viruses have been isolated from 12 different patients. Cytopathic changes, characterized by a syncytium, with giant cell formation and distinctive cytoplasmic inclusion bodies, have been demonstrated. No intranuclear inclusions were observed. These changes in cell culture preparations are illustrated in


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.