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Secondary Syphilis with Negative Serological Tests for Syphilis

Sanford M. Vaughan, M.C.
JAMA. 1961;176(9):825-826. doi:10.1001/jama.1961.03040220072028.
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To the Editor:—  A 40-year-old man was seen at the 97th General Hospital on Nov. 24, 1960, because of a generalized maculopapular eruption of 2-months duration. He gave a history of first developing a slightly pruritic papular eruption of the face in September, 1960. Within a month, the eruption had spread to involve the crural area, and later it became generalized, including the palms and soles. He had also noted transient twinges of pain in the right leg, commonly at night, for one month prior to admission, and he felt tired.There was no history of drug ingestion or sensitivity to vaccination, and 2 complement-fixation tests had been negative. He admitted to having extramarital contact in June, 1960. Physical examination revealed a generalized maculopapular eruption, including palms and soles, but no mucous membrane involvement or hair loss, and a generalized lymphadenopathy. Complement-fixation and flocculation tests were negative, but darkfield examination


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