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Serum Beta-Lipoproteins in the Preand Postmenopausal Female

Charles L. Heiskell, M.D.; Akira Yachi, M.D., Ph.D.; Herrick J. Aldrich, M.D.; Charles M. Carpenter, M.D., Ph.D.
JAMA. 1961;176(7):585-587. doi:10.1001/jama.1961.03040200021006.
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A specific immunochemical technique was used for the quantitative measurement of serum beta-lipoproteins in 124 premenopausal and 248 postmenopausal women. The mean premenopausal and postmenopausal levels were 1.9 ± 0.6 and 2.5 ± 1.0 immunocrit units, respectively. There was significant correlation of serum beta-lipoprotein levels with age for the group as a whole, but this appeared to have been the result of a relatively sharp rise in the mean level at the time of the menopause. Postmenopausal patients may benefit from estrogen-replacement therapy, not only for the relief of vasomotor symptoms but also because of the possible prophylactic effects with respect to eventual development of atherosclerotic disease.

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