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Granuloma Inguinale with Hematogenous Dissemination to the Spine

Bernard M. Kalstone, M.D.; James A. Howell Jr., M.D.; Frank X. Cline Jr., M.D.
JAMA. 1961;176(6):530-532. doi:10.1001/jama.1961.63040190012016c.
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GRANULOMA INGUINALE with metastases to bone is a comparatively rare occurrence. In the United States, primary granuloma inguinale has apparently been on the increase in the last few years as have the other venereal diseases. The placing of granuloma inguinale in the venereal category is actually an arbitrary one, as this condition has never been absolutely proved to be of venereal origin. It is the proclivity of this disease for the genital region that qualifies it to be listed as a venereal infection. In this paper granuloma inguinale and its complications will be reviewed, and a case of this disease with unusual sequelae will be presented.

Granuloma inguinale is a chronic granulomatous process that involves the skin and subcutaneous tissue of the genital region. The etiologic agent is the Donovan body. This is an intracellular inclusion body first described by Donovan in 1904. The true nature of the Donovan


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