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Carcinoma of the Parathyroid with Hyperparathyroidism and Metastases

Albert Ehrlich, M.D.; John McDonald, M.D.; Alfred Zitani Jr., M.D.
JAMA. 1961;176(5):453-455. doi:10.1001/jama.1961.63040180013016d.
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FUNCTIONAL CARCINOMA of the parathyroid gland is a rare disease. Based on criteria of endocrine hyperactivity and metastases or recurrent tumor, less than 30 cases have been reported in the literature.1,2,3,5,6 Albright and Reifenstein5 accepted only 3 cases up to 1948. The following case report of carcinoma of the parathyroid is of interest because the patient's severe clinical symptoms of hyperparathyroidism recurring 2 years after the removal of the primary tumor were associated with widespread cervical metastases.

Report of a Case  A 53-year-old man was admitted to St. Mary Hospital, Hoboken, N. J., for the first time in September, 1958, complaining of pain in the ankles, nausea, vomiting, and weakness of 2 months' duration. Pain in the tibial region was increased and was so severe that he had difficulty in walking.Physical examination on admission revealed a chronically ill, short, stocky white male with a pulse rate


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