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Tolbutamide in Treatment of Multiple Sclerosis and Parkinsonism

Edwin W. Gates, M.D.
JAMA. 1961;176(2):166-167. doi:10.1001/jama.1961.03040150082023.
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To the Editor:—  I had the opportunity to read the paper by Drs. Heller, DeJong, and Magee before it was published in this issue of The Journal, page 148, and I discussed it with Dr. Irving Hyman, who was the co-author with me on the preliminary report of "The Use of Tolbutamide in Paralysis Agitans."While I have no explanation for the failure of Drs. Heller, DeJong, and Magee to see any change in their patients, I would like to say more about the development of our findings.The first patient on whom the effects of tolbutamide in paralysis agitans were noted was in the hospital, as stated in our paper, he was unable to hold a cup of coffee without spilling it, even when he used both hands. This coarse tremor had been present for a long time. This so-called unstable diabetic was given tolbutamide in an attempt to


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