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Anticoagulant Therapy of Cryoglobulinemic Ulcers in a Case of Sjögren's Syndrome

John F. Foley, M.D.; Markle Karlen, M.D.; Cecil J. Watson, M.D.
JAMA. 1961;176(2):149-152. doi:10.1001/jama.1961.63040150010018c.
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IN 1947 Lerner and Watson1 introduced the term "cryoglobulin" to describe cold-precipitable serum globulins. Cryoglobulinemia may be divided into primary (essential) and secondary types. The first type has no known cause and is quite rare. The second type is found in association with neoplastic and infectious diseases and less often in a variety of other conditions.

It is not uncommon for patients with cryoglobulinemia to develop chronic leg ulcers. Treatment of this condition has been difficult. Domz and Feigin2 reported successful bishydroxycoumarin (Dicumarol) therapy of the ulcers associated with a case of essential cryoglobulinemia and outlined the rationale for its use based on the observations of Henstell and Feinstein.3 The following report describes a study of anticoagulation therapy in a case of essential cryoglobulinemia, with results confirming the observation of Domz and Feigin.

Report of a Case  A 40-year-old white female was admitted to the University of


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