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Carcinoma In Situ in Pregnancy

J. Ernest Ayre, M.D.; Joseph W. Scott, M.D.
JAMA. 1961;176(2):102-105. doi:10.1001/jama.1961.03040150018005.
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Carcinoma in situ is a frequent finding in pregnancy when cytologic methods are applied as a routine screening procedure. Such testing has been done without risk and has been applied at all stages. Cancer found when unsuspected and in a preclinical state rarely demands radical treatment. Modern management of early lesions which are preinvasive calls for conservative measures and cytologic follow-up, in contrast to clinical cancer, which demands immediate and often radical therapy. The recommended method for adequate biopsy is the cold-knife cone or "ring-biopsy" with the Ayre-Scott conization knife with disposable blade. Infiltration with 100 to 300 ml. of a saline-epinephrine solution makes it possible to excise the surgical specimen without loss of blood. Performed preferably after the third month of pregnancy, the conization procedure is safe.


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