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JAMA. 1961;175(13):1173-1174. doi:10.1001/jama.1961.03040130057015.
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The blood-sugar-lowering effect of aspirin in diabetic patients was demonstrated by Ebstein (1876) and Bartels (1878) in Germany, and by Williamson in England (1901). Its use was abandoned because of its failure in advanced cases and because of the frequent development of salicylism when large doses of aspirin were used. Recently interest in this subject has been renewed, stimulated perhaps by the introduction of other, more widely known, oral hypoglycemic agents.

To 12 diabetic and 13 non-diabetic patients from the wards and clinics of Kings County Hospital in Brooklyn, Hecht and Goldner1 administered minimal daily doses of 4.8 gm. of standard aspirin tablets for from 1 to 3 weeks. Marked hypoglycemic effects were obtained in both groups of patients, and the higher the glycosuria the more marked was the response to the action of aspirin. Two patients, whose fasting blood sugar levels initially were 62 and 86 mg.%, respectively,


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