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Adrenalectomy and Hypophysectomy in Disseminated Mammary Carcinoma

JAMA. 1961;175(9):787-790. doi:10.1001/jama.1961.63040090001009.
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AN IMPORTANT area in the palliative management of cancer is based on the manipulation of endocrine factors in carcinoma of the breast. The basic effort is the alteration of the hormonal milieu of the host, with the intent of creating a hormonal environment which is hostile to the continued growth of the neoplasm. The maximum effectiveness of such alterations becomes apparent as gross regression of neoplasm. The principal measures directed toward the production of such alterations are:

  • administration of hormones (androgens, estrogens, and corticosteroids); and

  • ablation of endocrine organs (ovaries, adrenals, and pituitary).

The relative usefulness of administered estrogens and androgens was studied, through a pooling of results from 60 investigators in as many institutions, by the Subcommittee on Breast and Genital Cancer, Committee on Research of the American Medical Association. The final report of this study was published only recently.1

The present communication is a preliminary


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