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Hypogammaglobulinemia ogammaglobulinemia

Beach Barrett, M.D.
JAMA. 1961;175(8):728-729. doi:10.1001/jama.1961.03040080084028.
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To the Editor:—  The paper on "Hypogammaglobulinemia" by Doctors Gordon and Spencer in The Journal, Sept. 17, 1960, page 269, presents a concept with which I disagree. They describe a vague group of patients who in no way fit the accepted criteria of the gamma globulin deficiency diseases, which are called either "hypogammaglobulinemia" or "agammaglobulinemia." As they point out, patients with classic cases of hypogammaglobulinemia suffer from a nearly complete, permanent deficiency of gamma globulin production. They present with severe, repeated bacterial infections. Such individuals can be readily identified by their very low levels of gamma globulin (0.002 gm. to 0.100 gm. per 100 ml. of serum). Effective therapy requires that their circulating gamma globulin content be maintained somewhere above 0.150 gm. per 100 ml. by the use of large monthly injections of gamma globulin. These patients apparently never recover the ability to make gamma globulin.Gordon and Spencer describe


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