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Salmonella Meningitis

Arthur J. Redmond, M.D.; Howard B. Slavin, M.D.
JAMA. 1961;175(8):708-709. doi:10.1001/jama.1961.63040080014020.
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SALMONELLA is rarely the cause of meningitis in the adult and is an infrequent clinical consideration. Central nervous system involvement is usually considered a disease of the newborn, or very early childhood,1 with three-fourths of the reported cases occurring under the age of 2 years.2 In this respect Salmonella shares the peculiar selectivity demonstrated by Hemophilus influenzae B meningitis.

Sporadic cases of Salmonella meningitis are mentioned in the older literature. However, no specific reference is noted in recent reports. Salmonella meningitis appears to carry a particularly high mortality. Five deaths occurred in 9 cases reported by MacCready.3 Henderson in 1948 recorded a mortality of 87 per cent of 147 patients. Henderson's report included 19 patients treated with sulfonamides and one treated with penicillin without obvious therapeutic effect.4 Beene, in 1951, noted a mortality of 83 per cent of 87 cases, some treated with penicillin or tetracycline


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