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Renal Vein Thrombosis in Infants

Louis A. Vega, M.D.
JAMA. 1961;175(6):500-501. doi:10.1001/jama.1961.63040060006021.
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RENAL VEIN thrombosis is a condition that appears mostly in the first weeks of life, usually as a complication of severe diarrhea and dehydration,1 characterized by gross hematuria, albuminuria, oliguria, azotemia, and, usually, a palpable abdominal mass.

It was pointed out by Barenberg2 in 1941 that the physicians of the nineteenth century regarded renal vein thrombosis a common occurrence in young infants. However, most of the recent reports on this condition consider the diagnosis rarely made clinically. McClelland and Hughes3 in 1950 reported only three cases from a review of 328 autopsies in infants. Kobernick, Moore, and Wiglesworth4 in 1951 reported on four cases found among 1,092 autopsies in infants over a period of 12 years.

It appears that Campbell and Matthews5 were the first to make the clinical diagnosis of this condition in this country in 1941. Apparently, up to 1956 only a


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