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Infantile Cortical Hyperostosis

John P. Tampas, M.D.; Frederick W. Van Buskirk, M.D.; Oscar S. Peterson Jr., M.D.; A. Bradley Soule, M.D.
JAMA. 1961;175(6):491-493. doi:10.1001/jama.1961.63040060003014.
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Infantile cortical hyperostosis was first described and named by Caffey and Silverman in 1945.4 Smyth, Potter, and Silverman12 described a similar group of cases in a separate and independent report the next year. These reports stimulated a great deal of interest in the disease, and by 1952 there were over 100 case reports in the literature. It soon became apparent that infantile cortical hyperostosis, rarely recognized before its description in 1945, was now diagnosed and reported with increasing frequency. Yet, although the number of cases of infantile cortical hyperostosis seems to be increasing, and in spite of the fact that the disease is recognized in pediatric practice so commonly that only cases of unusual interest are now being published, our experience of having observed 11 cases in 2 generations of one family reveals that much is still to be learned about this interesting entity.

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