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Menstrual Irregularities Associated with Use of Methaminodiazepoxide

M. James Whitelaw, M.D.
JAMA. 1961;175(5):400-401. doi:10.1001/jama.1961.63040050006021.
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DURING THE PAST 4 years several reports1-6 have appeared on the effect of phenothiazine ataraxic drugs on the reproductive functions of animals and the human female. Recently a new non-phenothiazine ataraxic drug, methaminodiazepoxide hydrochloride (Librium), has found widespread use in the treatment of mild anxiety states and nervous disorders. There has been no published evidence, experimental or clinical, to suggest that it has any effect on the hypothalamic pituitary ovarian axis.7 Because of the profoundly disturbing effects on the female reproductive cycle associated with the administration of minimal amounts of this drug, this report is given.

Material  Seventeen normally menstruating women, all infertility patients who had been under observation for a minimum of 5 months and whose basal body temperature patterns were normal, were given methaminodiazepoxide hydrochloride because of evidence of tubal spasm or nervous tension. The drug was given 3 times a day for 4 days, usually starting


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