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Use of Silicone in the Treatment of Intestinal Gas and Bloating

J. Alfred Rider, M.D., Ph.D.; Hugo C. Moeller, M.D., Ph.D.
JAMA. 1960;174(16):2052-2054. doi:10.1001/jama.1960.03030160038009.
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Silicone defoamers have been used successfully to eliminate the mucuscovered bubbles which obstruct a gastroscopist's view of the stomach. This led to their trial in treating patients complaining of flatulence and distention. Two hundred patients, aged 23 to 84 years, were given methyl polysiloxane, a physiologically inert silicone, for four weeks to three and a half years. Although other measures had not relieved symptoms, 40 mg. of methyl polysiloxane taken orally 4 times daily produced excellent or good results in 151 patients. In a control group of 20 patients who had had excellent or good results from the methyl polysiloxane, the substitution of a lactose placebo was followed by renewed complaints within 24 hours in 18 patients.


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