Tin Anniversary of the Development of Live Virus Vaccine

Hilary Koprowski, M.D.
JAMA. 1960;174(8):972-976. doi:10.1001/jama.1960.63030080001006.
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TEN YEARS ago we found that the oral administration of live attenuated poliovirus to a small group of nonimmune children gave rise to an asymptomatic intestinal infection, followed by the appearance of antibodies in the blood.1 At the Second International Conference on Live Poliovirus Vaccines, held in Washington, D. C., June, 1960, reports were presented showing that over 60,000,000 people in many parts of the world have been given live attenuated poliovirus for immunization purposes.

These two events frame a decade of progress in research, extending from a small and hopeful beginning to undertakings of present magnitude. The purpose of this paper is to examine the canvas within this frame—the background sketched in 1950 and the figures now occupying the foreground painted in during the rest of the decade. I shall be guided in this task by Salvador Dali's exemplary saying: "I do not paint a portrait to look


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