0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

The "Toxin-Antitoxin" Phenomenon in Burned and Injured Human Subjects

Sol R. Rosenthal, Ph.D., M.D.; James B. Hartney, M.D.; Wilma A. Spurrier, B.S.
JAMA. 1960;174(8):957-965. doi:10.1001/jama.1960.03030080019004.
Text Size: A A A
Published online

The presence of toxins in the blood of burned or otherwise injured patients was indicated by the demonstration of cytotoxic effects on HeLa cells, cytolytic effects on red cells of other burned or injured patients, and precipitogens against serums from patients with healed burns. Such serums were shown to contain anti-toxic-antibody-like substances by demonstrating their ability to neutralize the cytotoxic effect on HeLa cells and by demonstrating the presence of hemolysins and precipitins. In preliminary clinical trials the transfusion of blood or plasma from donors with healed burns to critically toxic burned or injured patients was followed by prompt improvement. Serums obtained from the recipients after such transfusions were no longer toxic to tissue cultures. The authors recommend further clinical trials of antisera of known titer from persons with healed burns.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();