JAMA. 1960;174(5):521-522. doi:10.1001/jama.1960.03030050063019.
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For many years physiologic methods have been applied to the clinical study of dynamic processes operative in disease states. During the past 15 years specialized techniques, such as radioisotopes, radioautography, electrophoresis, histochemistry, and electronmicroscopy, have augmented the clinician's diagnostic armamentarium as well as supplemented the study of clinical phenomena. No longer is it necessary to rely solely on the post-mortem correlation of pathologic physiology with pathologic anatomy. For many years clinicians have hoped for the development of in vivo methods of study which might aid the diagnosis, clinical evaluation, and management of patients with specific disease entities. The marriage of the anatomic with the physiologic and clinical disciplines for the benefit of the clinician, as well as the patient, has now taken place. Serial liver biopsies, lung biopsies, renal biopsies, and even myocardial biopsies have given the clinician the hitherto unavailable opportunity to observe anatomic changes as they occur in


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