Attention has been focused upon sarcoidosis intermittently over the last century. The numerous communications have reported studies of its clinical features1 and pathology, and deliberations on its possible relationship to tuberculosis.2 Schaumann's classic dissertation established that the disease, first described by Hutchinson in 1869 and known as lupus pernio and Boeck's sarcoid, attacked not only the skin but might involve the internal organs as well. He drew attention to the negative tuberculin reaction, even though the histological lesions were tuberculoid in appearance. Despite continued investigations and a resurgence of interest, the enigma of the etiology remains. Yet, advances have been made in therapy, and symptomatic relief can be expected from the corticosteroids. In this issue of The Journal, p. 380, Goetz discusses the biochemical alterations caused by the disease and the beneficial effects of steroid administration.
Sarcoidosis may be a collection of clinical syndromes with possibly more than