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Unusual Allergic Reaction to Iron-Dextran Complex

Lawrence R. Loftus, M.D.
JAMA. 1960;174(3):302-303. doi:10.1001/jama.1960.63030030010022.
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Since its introduction into this country two years ago, iron-dextran complex (Imferon) has been used quite widely. Few severe allergic manifestations have been reported. The following case report concerns an apparent allergic reaction to iron-dextran complex which has not previously been reported in the medical literature. It is substantiated by a microscopic pathology report.

Report of a Case  A 45-year-old woman was hospitalized on July 3, 1959, for a hysterectomy because of a uterine fibroid tumor which had been growing rapidly over the previous year. She had normal menstrual periods, and Papanicolaou smears gave normal findings. Her own history, family history, and review of systems were noncontributory. No previous allergies had been noted. Physical examination gave entirely normal findings, except for a 1-cm. nodule in the left breast and a large irregular uterus. The spleen could not be felt, and no lymph nodes were palpable.On July 4, 1959, the


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