The Physiological Basis of Diuretic Therapy

Paul S. Rhoads, M.D.
JAMA. 1960;174(1):94. doi:10.1001/jama.1960.03030010096035.
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Here is a book that should be of great use to those who read it carefully. The wondrous manner in which body water goes in and out of the vascular bed and is conserved and eliminated by the kidneys is still imperfectly understood. However, those things which are known or strongly suspected are set forth in terms which even the less sophisticated reader should understand. The many gaps in our knowledge are pointed out with equal clarity. If modern views of the astonishing properties of renal tubular epithelial cells are correct, they must be among the most versatile cells possessed by man. The complex activity going on in the kidney, however, is no more exciting than that occurring simultaneously in the lungs—"In the second or so required for an erythrocyte to traverse a pulmonary capillary, bicarbonate ion must diffuse into the erythrocyte in exchange for chloride ion and associate with


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