0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

AUTOANTIBODIES AND RHEUMATOID ARTHRITIS

JAMA. 1960;174(1):66-67. doi:10.1001/jama.1960.03030010068016.
Text Size: A A A
Published online

ABSTRACT

The harmful action of antibodies administered to an animal which possesses the corresponding antigens was recognized by Bordet in 1898. The injection of serum of a guinea pig immunized with rabbit erythrocytes caused disease and death of the rabbits. The refusal of a sound organism to produce autoantibodies became apparent, and was expressed specifically in 1901 by Ehrlich who coined the famous term horror autotoxicus—the fear of the living organism to produce antibodies harmful to its own tissues. Ehrlich's view has been substantiated basically; however, there is experimental evidence that under natural and experimental conditions antibodies may appear which react in vitro with antigens diverted from the producer of the antibodies. These findings have promoted a steadily increasing number of research projects and speculations on the role of disease-inducing autoantibodies in vivo. Thus a new branch of medicine, immunopathology, has evolved. Certain criteria have been enumerated for the recognition

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();