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John B. McDonald, M.D.; Robert W. Edwards, M.D.
JAMA. 1960;173(11):1205-1209. doi:10.1001/jama.1960.03020290031006.
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It is proposed that Wegener's granulomatosis be considered a clinicopathological triad, since it involves primarily three systems: vascular, respiratory, and renal. Pathologically, it is a focal necrotizing vasculitis which involves both arteries and veins and produces necrotizing granulomas of the respiratory tract and a focal glomerulonephritis. Clinically, it is manifested by intractable rhinitis and sinusitis, nodular pulmonary lesions, and terminal uremia. The recognition of these findings as a triad facilitates earlier diagnosis. The criteria outlined were fulfilled in the case, here presented, of a 57-year-old man. The treatment included administration of antibiotics and steroids, but did not appear to affect the outcome of the disease. The etiology is unknown.


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