Samuel M. Bluefarb, M.D.; Charles L. Schmitt, M.D.; Charles M. Howell Jr., M.D.
JAMA. 1960;173(1):40-41. doi:10.1001/jama.1960.73020190003009a.
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The proper management of acne vulgaris is multiphasic. In addition to systemic measures aimed at reducing sebaceous gland activity, therapy should include topical measures designed to achieve a continuous mild drying and peeling of the skin, to remove excessive oiliness and prevent follicular obstruction and the consequent development of comedones. For this purpose antiseborrheic lotions with a neocalamine base, containing one or more keratolytics such as resorcinol, sulfur, or salicylic acid, are commonly used. This clinical note contains the evaluation of a new acne drying lotion with a nonionic surfactant which, in the presence of calamine powders, appears to have the drying properties of resorcinol and potentiates the keratolytic action of sulfur. During the formulation of a topical medicament, in which appropriate solvents for hexachlorophene were sought, one such solvent tried, polyoxyethylene lauryl ether (a nonionic surfactant produced by the condensation of ethylene oxide with lauryl alcohol), was observed to


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