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MANAGEMENT OF DIFFUSE METASTASIS FROM CARCINOMA OF THE PROSTATE

Orliss Wildermuth, M.D.; Dean Parker, M.D.; John O. Archambeau, M.D.; Chahin Chahbazian, M.D.
JAMA. 1960;172(15):1607-1611. doi:10.1001/jama.1960.03020150031006.
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Testosterone was administered to five patients suffering from metastases in carcinoma of the prostate. In each case the patient had diffuse metastatic lesions in bones and was no longer responding to estrogens, castration, or steroids. The testosterone was given in an attempt to stimulate bone and tumor metabolism and also to enhance the uptake of radioactive phosphorus for a therapeutic effect. The results are exemplified in the case of a man, aged 59 years, with bony metastases that had resulted in multiple fractures of ribs and vertebrae. After five days of treatment with testosterone, he received 2 mc. of radioactive phosphorus (P32) every other day to a total of 20 mc. The beneficial effects were striking though temporary; it was not until the fourth month than any pain returned.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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