In this book the relations of pyelonephritis to uremia, obstructive uropathy, diabetes, pregnancy, and hypertension are illustrated by case histories. The forms encountered in infancy and childhood and the evolution from acute or latent subclinical disease are fully discussed. The literature and history of knowledge of pyelonephritis are also given. This is a brief but well-balanced monograph by a careful observer with great experience in the field. His discussion of therapy and his discouraging report on the value of antibiotics in the chronic or subacute disorder should be read by every internist and pediatrician. The techniques for identifying unilateral disease as a possible cause of hypertension and the way in which diabetes, hypertension, and proteinuria predispose the kidney to hematogenous infection are not stressed. However, these are of more concern to specialists and pathologists than to the larger group for which this book was written.