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The Radioisotope Renal Excretion Test

Chester C. Winter, M.D.
JAMA. 1962;181(6):560-561. doi:10.1001/jama.1962.03050320098010d.
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STANDARD RENAL CLEARANCE tests, whether they are the Van Slyke or dye-recovery methods, are time-consuming and difficult to perform. The inulin, mannitol, iodopyracet compound (Diodrast) and para-amino-hippurate clearance procedures have remained within the province of the experimental laboratory. Of the serum clearance determinations, only those of urea and endogenous creatinine are in general clinical use. The former fluctuates widely with the state of the patient's hydration and is generally unreliable, while the latter is employed with increasing frequency, both for the study of the function of the individual kidney among hypertensive patients and before renal surgery. The serum creatinine suffices for the evaluation of total renal function. The estimations of time of appearance and intensity of color of indigo carmine and méthylène blue, as seen in the urine coming from the ureteral orifices, through the cystoscope, are so crude as to be only quick guesses as measures of individual renal


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