EVER SINCE the high fat Sippy diet was first introduced in 1915 for the treatment of peptic ulcer, numerous clinical studies have attested to the rationale of this form of therapy in patients with active symptomatology. During recent times much evidence has accumulated which tends to align coronary atherosclerosis with the dietary intake of fats, particularly of the saturated variety. This, plus statistical data showing an increased incidence of myocardial infarctions in ulcer patients who have been treated with Sippy diets now make it necessary to reappraise this treatment in terms of its possible deleterious implications.
The present study was undertaken to obtain more definitive information as to the specific effects of a Sippy feeding regimen on the serum lipids and fat tolerance.
Methods and Material Sixteen consecutive hospitalized patients having active duodenal ulcers, and 5 normal volunteers were selected for investigation (Table 1). In half of the ulcer group,