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A Five-Year Study of Tolbutamide in the Treatment of Diabetes Mellitus

DeWitt E. DeLawter, M.D.; James M. Moss, M.D.
JAMA. 1962;181(2):156-158. doi:10.1001/jama.1962.03050280086013.
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THE ULTIMATE value of the sulfonylurea drugs in the management of the mild "adult type" diabetic is being determined by the accumulation of results in patients taking the drugs over a long period of time. The 5-year follow-up of 200 patients who started taking tolbutamide in 1956, is reviewed for evaluation of the effectiveness of this sulfonylurea preparation. This group has been reported previously after 12, 24, and 36 months of treatment.


The 200 patients selected for this study consisted of 105 treated in the Diabetic Clinic of the Georgetown University Hospital and 95 treated in our private offices. All were instructed to follow a measured diet, but it was obvious that many of them made no change in their food habits. Tolbutamide (Orinase) was used in the smallest effective dose. The tolbutamide response test was not used in the selection of our patients, but the drug was offered to


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