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Edward Pickert, M.D.
JAMA. 1960;172(10):1083. doi:10.1001/jama.1960.03020100091022.
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To the Editor:—  The clinical note in The Journal, Sept. 26, 1959, page 415, is a case report entitled "Hypersensitivity to Immune Serum Globulin." The publication of this seems unfortunate to me, since both diagnosis and treatment are open to question. The inaccuracies which it contains could lead to disaster in circumstances of a similar nature. The concept of spontaneous hypersensitivity to human immune serum globulin is hardly borne out by any of the evidence or comments printed. The fact that both parents had a strong allergic history scarcely gives any additional credibility to this diagnosis, in a 15-week-old child who has yet to manifest one symptom of an allergic nature despite the fact that it has met and apparently overcome successfully innumerable antigens.Even the comments of the consultant which are included contain rather misleading statements; e. g., speaking of the possibility of allergy, "The mechanism is of some


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