December 5, 1959, Vol 171, No. 14 >

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ARTICLE | December 5, 1959

PROMETHAZINE DRIP IN THE POSTOPERATIVE MANAGEMENT OF SUPRAPUBIC PROSTATECTOMY

Ben Sheiner, M.D.; Bernard D. Pinck, M.D.

JAMA. 1959;171(14):1955-1957. doi:10.1001/jama.1959.03010320045010.

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The danger of extravasations of blood and urine after suprapubic prostatectomy is increased in patients made restless by pain and by reflexes arising from the region of the bladder. Prolonged, heavy sedation with narcotics alone is undesirable in elderly patients. The possibility that better results might be obtained by administering a combination of a narcotic and promethazine hydrochloride was investigated in 82 patients who had undergone suprapubic prostatectomy under spinal anesthesia. All received meperidine or morphine as needed for pain. Patients in group 1 (41 patients) in addition received promethazine by intravenous drip; those in group 2 (34 patients) received no promethazine; and those in group 3 (7 patients) received promethazine intramuscularly. Patients in group 1 remained free from nausea, vomiting, chills, and cold sweats; tolerated postoperative bladder irrigations without reflex spasms or hemorrhages; and required, on the average, less than half the dose of narcotics required in group 2. No untoward effects were observed.

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Sheiner B, Pinck BD. PROMETHAZINE DRIP IN THE POSTOPERATIVE MANAGEMENT OF SUPRAPUBIC PROSTATECTOMY. JAMA. 1959;171(14):1955-1957. doi:10.1001/jama.1959.03010320045010.

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PROMETHAZINE DRIP IN THE POSTOPERATIVE MANAGEMENT OF SUPRAPUBIC PROSTATECTOMY

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