We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Stanley Wallach, M.D.; Philip H. Henneman, M.D.
JAMA. 1959;171(12):1637-1642. doi:10.1001/jama.1959.03010300011002.
Text Size: A A A
Published online


The fact that estrogens have now been in therapeutic use for more than 25 years made it possible to examine the evidence for their safety and effectiveness in a study of 292 postmenopausal women. The mean duration of estrogen therapy in this group was 5.1 years per patient. The estrogens most used since 1945 have been diethylstilbestrol and conjugated equine estrogens, and the latter have been tolerated without side-effects by almost all patients. Among the commoner symptoms of the menopause, hot flashes were completely relieved in 93 of 94 patients. Postmenopausal osteoporosis was treated by prolonged estrogen therapy in 119 patients, 103 of whom had suffered collapse of vertebrae; either complete or significant relief from pain occurred in 90%. Evidence that estrogen therapy is prophylactic against postmenopausal osteoporosis was obtained in a group of 27 women. A study of the incidence of tumors among the 292 patients yielded no justification for the fear that mammary and cervical carcinoma may result from this therapy.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.